Saini, RK and Agarwal, A
(2021)
Low Cost Paper-based SERS Sensor using Gold Nanoparticles for Molecular Detection.
In: 1st International Conference on Micro/Nanoelectronics Devices, Circuits and Systems (MNDCS-2021), January 30-31, 2021, NIT Silchar, Assam, India.
Abstract
SERS (Surface Enhanced Raman Spectroscopy or Surface Enhanced Raman Scattering) is a surface sensitive technique. and enhanced form of Raman spectroscopy. In this technique, nanostructures provide hotspots for the analyte detection, which enhances the Raman signal 1010-1011 times higher signal compared to the normal Raman spectroscopy. SERS is a very powerful technique for quantitative and qualitative analysis of various molecules. The technique is highly sensitive and can detect even a single molecule of the sample. These sensors can be used to detect variety of biological and chemical samples. This research work presents the development of the SERS substrate using gold nanoparticles. Rhodamine B, a marker molecule is used to determine the intensity enhancement capability of the substrates. Raman spectrometer and Uv-vis spectrophotometer is used for measurement. Gold nanoparticles, sized 40-45 nm, were deposited on the porous cellulose paper; developing the Nano-gaps between the particles. Electromagnetic coupling occurs in the Nano-gaps which is responsible for electromagnetic enhancement. Availability of large number of hot-spots on the substrate leads to better enhancement. We used 106 M Rhodamine samples to characterize the SERS substrate. 105 fold enhancement in Raman signal with uniform intensity was achieved. These type of low cost paper sensors will find numerous biochemical and bioanalytical application.
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